While working on a batch glTF exporter for Blender, I wrote a script.reload_addon operator to make it easier to update a single add-on during its development. It’s faster than the built-in script.reload operator, and it does not affect the state of other add-ons. Most importantly, it adds shortcut keys for both!
Get all the details on how to install, configure, and use it at the add-on’s GitHub repository.